We all know how flexible and ever-changing and adapting English is...
Words and structures that were unacceptable yesterday are perfectly fine today, and even get into dictionaries and grammar books. English is living and changing.
The first thing that springs to my mind id "There IS a large number of people" because "number" is singular.
However, maybe things depend on what we want to stress?
Imagine stressing "number":
"There IS a large number of people..."
And then imagine stressing "people":
"There ARE a large number of people who just can �t get away from ESL Printables and get some housework done".
Is it possible that both are correct?..
Because neither seems completely wrong.
Or maybe "There is a large number" is more traditional, and "There are a large number" is more everyday language?
Or maybe if we do say "There are a large number..." the phrase must always be followed by the object ("people"), however the phrase "There is a large number." is fine on its own.
Just thoughts...